5 Chapter 5 Maggot excretions inhibit the human complement system Maggot excretions inhibit complement
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Maggot Excretions Inhibit Biofilm Formation on Biomaterials
BACKGROUND Biofilm-associated infections in trauma surgery are difficult to treat with conventional therapies. Therefore, it is important to develop new treatment modalities. Maggots in captured bags, which are permeable for larval excretions/secretions, aid in healing severe, infected wounds, suspect for biofilm formation. Therefore we presumed maggot excretions/secretions would reduce biofilm...
متن کاملThe influence of maggot excretions on PAO1 biofilm formation on different biomaterials.
Biofilm formation in wounds and on biomaterials is increasingly recognized as a problem. It therefore is important to focus on new strategies for eradicating severe biofilm-associated infections. The beneficial effects of maggots (Lucilia sericata) in wounds have been known for centuries. We hypothesized sterile maggot excretions and secretions (ES) could prevent, inhibit, and break down biofil...
متن کاملMaggot debridement therapy in chronic wound care.
OBJECTIVE To review the current evidence on the mechanism of actions and clinical applications of maggot debridement therapy. DATA SOURCES Literature search of PubMed and Medline was performed up to January 2007. STUDY SELECTION Original and major review articles related to maggot debridement therapy were reviewed. Key words used in the literature search were 'maggot debridement therapy', '...
متن کاملSelective Antibiofilm Effects of Lucilia sericata Larvae Secretions/Excretions against Wound Pathogens
Background. Maggot debridement therapy (MDT), using Lucilia sericata larvae, represents efficient, simple, and low-cost therapy for the treatment of chronic wounds. Aim. The aim was to investigate the antibiofilm activity of maggot excretions/secretions (ES) against biofilm of wound isolates Staphylococcus aureus (S. aureus), Enterobacter cloacae (E. cloacae), and Proteus mirabilis (P. mirabili...
متن کاملNext Generation Sequencing Identifies Five Major Classes of Potentially Therapeutic Enzymes Secreted by Lucilia sericata Medical Maggots.
Lucilia sericata larvae are used as an alternative treatment for recalcitrant and chronic wounds. Their excretions/secretions contain molecules that facilitate tissue debridement, disinfect, or accelerate wound healing and have therefore been recognized as a potential source of novel therapeutic compounds. Among the substances present in excretions/secretions various peptidase activities promot...
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